The following selection of publications demonstrates PHENOS scientific background:


Balzer MS, Helmke A, Ackermann M, Casper J, Dong L, Hiss M, Kiyan Y, Rong S, Timrott K, von Vietinghoff S, Wang L, Haller H, Shushakova N.

Protein kinase C beta deficiency increases glucose-mediated peritoneal damage via M1 macrophage polarization and up-regulation of mesothelial protein kinase C alpha.
Nephrol Dial Transplant. 2018 Sep 21.[Epub ahead of print]
PMID: 30247663


Wang L, Balzer MS, Rong S, Menne J, von Vietinghoff S, Dong L, Gueler F, Jang MS, Xu G, Timrott K, Tkachuk S, Hiss M, Haller H, Shushakova N.

Protein kinase C a inhibition prevents peritoneal damage in a mouse model of chronic peritoneal exposure to high-glucose dialysate.
Kidney Int. 2016 Jun;89(6):1253-67.
PMID: 27142955


Gueler F, Shushakova N, Mengel M, Hueper K, Chen R, Liu X, Park JK, Haller H, Wensvoort G, Rong S.

A novel therapy to attenuate acute kidney injury and ischemic allograft damage after allogenic kidney transplantation in mice.
PLoSOne. 2015 Jan 24;10(1):e0115709.
PMID: 25617900


Rong S, Hueper K, Kirsch T, Greite R, Klemann C, Mengel M, Meier M, Menne J, Leitges M, Susnik N, Meier M, Haller H, Shushakova N, Gueler F.

Renal PKC-e deficiency attenuates acute kidney injury and ischemic allograft injury via TNF-a-dependent inhibition of apoptosis and inflammation.
Am J Physiol Renal Physiol. 2014 Sep 15;307(6):F718-26.
PMID: 25056349


Menne J, Shushakova N, Bartels J, Kiyan Y, Laudeley R, Haller H, Park JK, Meier M.

Dual inhibition of classical protein kinase C-α and protein kinase C-β isoforms protects against experimental murine diabetic nephropathy. Diabetes.2013 Apr;62(4):1167-74.
PMID: 23434935


Lu X, Li N, Shushakova N, Schmitt R, Menne J, Susnik N, Meier M, Leitges M, Haller H, Gueler F, Rong S.

C57BL/6 and 129/Sv mice: genetic difference to renal ischemia-reperfusion.
J Nephrol. 2012 Sep-Oct;25(5):738-43.
PMID: 22180224


Blume C, Felix A, Shushakova N, Gueler F, Falk CS, Haller H, Schrader J.

Autoimmunity in CD73/Ecto-5'-nucleotidase deficient mice induces renal injury. PLoS One. 2012;7(5):e37100.
PMID: 22666342


Bertram A, Zhang H, von Vietinghoff S, de Pablo C, Haller H, Shushakova N, Ley K.

Protein kinase C-Θ is required for murine neutrophil recruitment and adhesion strengthening under flow. J Immunol. 2012 Apr 15;188(8):4043-51.
PMID: 22403440


Kumpers P, Gueler F, David S, Slyke PV, Dumont DJ, Park JK, Bockmeyer CL, Parikh SM, Pavenstadt H, Haller H, Shushakova N.

The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Crit Care. 2011;15(5):R261.
PMID: 22040774


Sörensen I, Rong S, Susnik N, Gueler F, Shushakova N, Albrecht M, Dittrich AM, von Vietinghoff S, Becker JU, Melk A, Bohlmann A, Reingruber S, Petzelbauer P, Haller H, Schmitt R.

Bβ(15-42) attenuates the effect of ischemia-reperfusion injury in renal transplantation. J Am Soc Nephrol. 2011 Oct;22(10):1887-96.
PMID: 21841063


David S, Park JK, Meurs Mv, Zijlstra JG, Koenecke C, Schrimpf C, Shushakova N, Gueler F, Haller H, Kümpers P.

Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis. Cytokine. 2011 Aug;55(2):251-9.
PMID: 21531574


Gueler F, Rong S, Gwinner W, Mengel M, Bröcker V, Schön S, Greten TF, Hawlisch H, Polakowski T, Schnatbaum K, Menne J, Haller H, Shushakova N.

Complement 5a receptor inhibition improves renal allograft survival.
J Am Soc Nephrol. 2008 Dec;19(12):2302-12.
PMID: 18753257


Gueler F, Park JK, Rong S, Kirsch T, Lindschau C, Zheng W, Elger M, Fiebeler A, Fliser D, Luft FC, Haller H.

Statins attenuate ischemia-reperfusion injury by inducing heme oxygenase-1 in infiltrating macrophages.
Am J Pathol. 2007 Apr;170(4):1192-9.
PMID: 17392159


Meier M, Menne J, Park JK, Holtz M, Gueler F, Kirsch T, Schiffer M, Mengel M, Lindschau C, Leitges M, Haller H.

Deletion of Protein Kinase C-{varepsilon} Signaling Pathway Induces Glomerulosclerosis and Tubulointerstitial Fibrosis In Vivo.
J Am Soc Nephrol. 2007 Apr;18(4):1190-8. Epub 2007 Mar 14.
PMID: 17360953


Meier M, Park JK, Overheu D, Kirsch T, Lindschau C, Gueler F, Leitges M, Menne J, Haller H.

Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model.
Diabetes. 2007 Feb;56(2):346-54.
PMID: 17259378


Menne J, Meier M, Park JK, Boehne M, Kirsch T, Lindschau C, Ociepka R, Leitges M, Rinta-Valkama J, Holthofer H, Haller H.

Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo.
Kidney Int. 2006 Oct;70(8):1456-62. Epub 2006 Sep 6.
PMID: 16955103


Ziegler E, Gueler F, Rong S, Mengel M, Witzke O, Kribben A, Haller H, Kunzendorf U, Krautwald S.

CCL19-IgG prevents allograft rejection by impairment of immune cell trafficking.
J Am Soc Nephrol. 2006 Sep;17(9):2521-32. Epub 2006 Aug 9.
PMID: 16899521


Menne J, Park JK, Agrawal R, Lindschau C, Kielstein JT, Kirsch T, Marx A, Muller D, Bahlmann FH, Meier M, Bode-Boger SM, Haller H, Fliser D.

Cellular and molecular mechanisms of tissue protection by lipophilic calcium channel blockers.
FASEB J. 2006 May;20(7):994-6. Epub 2006 Apr 5.
PMID: 16597674